Cell Lineage Choice during Haematopoiesis: In Honour of Professor Antonius Rolink

Geoffrey Brown,Rhodri Ceredig

doi:10.3390/ijms19092798

Abstract

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Highlights

The DECIDE network initially arose from the shared interests of Drs Ceredig, Brown, and Rolink in the subject of the process of blood cell formation, or haematopoiesis, and in particular, how progenitor cells differentiate to give rise to the different blood cell types
After an early bifurcation, lymphocytes derive from a common lymphocyte progenitor (CLP), whereas myeloid cells derive from a common myeloid progenitor (CMP)
With the help of two early stage researchers employed by the DECIDE network working in Ton’s laboratory (Audrey Lilly von Münchow and Llucia Alberti Servera) and two in

Summary

Introduction

The DECIDE (decision-making within cells and differentiation entity therapies) network initially arose from the shared interests of Drs Ceredig, Brown, and Rolink in the subject of the process of blood cell formation, or haematopoiesis, and in particular, how progenitor cells differentiate to give rise to the different blood cell types. Work with cell lines had demonstrated that the B-cell and myeloid lineages were more closely related than what was envisaged by the “classical” model of haematopoiesis. The seminal papers from Ton’s laboratory describing cell lines deficient in the transcription factor Pax-5 and with a multi-lineage (including lymphoid, in this case T-cell and myeloid) potential contributed to the need to rethink models of haematopoiesis [3,4].

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