Abstract

The problem of the origin of tumors is a part of the physiology of growth. In explaining malignant tumors pathologists made use of two of the most obvious instances of ordinary tissue growth, namely, embryonic development and regenerative phenomena. Accordingly two theories have been advanced to explain tumor growth. The first one explains tumors as originating from embryonal cells, either actually detached from their normal surroundings, or at least functionally detached. With or without changing their place these cells do not take part in the further development of their neighbors; they remain in an embryonal condition, are not functionally active as the normal surrounding tissue is, until at a later period they begin to make use of their latent, stored up forces. Being locally or functionally disconnected they do not find the tension of the neighboring cells opposed to them and they can now grow indefinitely. This is, in the

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