Abstract
(Abstracted from Am J Obstet Gynecol 2023;229:435.e1–435.e7 Cell-free DNA (cfDNA) screening is an effective way to identify trisomy 21 in singleton pregnancies and has been shown to have both a high detection rate and a low false-positive rate. For twin pregnancies, however, there are challenges relating to fetal fraction and the ability to obtain and distinguish fetal DNA.
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