Abstract
Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition and the lack of a biomarker able to accurately confirm the condition, the diagnosis of sepsis is challenging. Even more challenging is the prediction of how these patients will respond to the therapy and whether they will survive the intensive care and the hospital admission.
Highlights
Severe sepsis can be a catastrophic condition that is often associated with poor outcomes
Free circulating nucleic acids in plasma and serum have been studied as biomarkers [4]
In the previous issue of Critical Care, Dwivedi et al [11] confirmed the prognostic abilities of cell-free DNA (cfDNA) in severe sepsis
Summary
Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. Many different compounds have been assessed either to diagnose the condition or to prognosticate between a good and a poor outcome in patients in whom the problem has already been diagnosed. Levels of cfDNA are detectable in healthy individuals; second, raised levels are not specific to a single disease.
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