Abstract
Purpose/Objective: Response to ionizing radiation (IR) is modified in part by interactions between cells and the microenvironment. Integrins are an important class of molecules that mediate critical cues between cells and the extracellular matrix (ECM). β1 integrin has been shown to modify response to cytotoxic chemotherapy in lung, leukemia and colon cancers and has been shown to play a critical role in expression of the breast cancer phenotype. We hypothesize that β1 integrin is a potential molecular target in breast cancer, and modulating β1 integrin function may sensitize cells to the effects of IR.
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