Abstract
Cell death inhibition by KSHV.
Highlights
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of the endothelial cell-derived tumor Kaposi’s sarcoma and of the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman's disease
Other studies suggested that K13/vFLIP may inhibit apoptosis by blocking caspase-8 activation in the apoptotic death-inducing signaling complex (DISC)
In contrast it was hypothesized that K13/vFLIP may induce necroptosis in infected cells [7] because insufficient caspase 8 activity has been identified as a key parameter in the induction of necroptosis [8]
Summary
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of the endothelial cell-derived tumor Kaposi’s sarcoma and of the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman's disease. Other studies suggested that K13/vFLIP may inhibit apoptosis by blocking caspase-8 activation in the apoptotic death-inducing signaling complex (DISC). In contrast it was hypothesized that K13/vFLIP may induce necroptosis in infected cells [7] because insufficient caspase 8 activity has been identified as a key parameter in the induction of necroptosis [8].
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