Abstract
Cell division and cell cycle mechanism has been studied for 70 years. This research has revealed that the cell cycle is regulated by many factors, including cyclins and cyclin-dependent kinases (CDKs). Heat shock transcription factors (HSFs) have been noted as critical proteins for cell survival against various stresses; however, recent studies suggest that HSFs also have important roles in cell cycle regulation-independent cell-protective functions. During cell cycle progression, HSF1, and HSF2 bind to condensed chromatin to provide immediate precise gene expression after cell division. This review focuses on the function of these HSFs in cell cycle progression, cell cycle arrest, gene bookmarking, mitosis and meiosis.
Highlights
The mitosis phenomenon was discovered over one hundred years ago, and many scientists have performed experiments to make novel discoveries
They previously found that SUMOylation upregulates the DNA binding activity of HSF2 [64], and the SUMOylation accelerated HSF2 and CAP-G interaction in mitotic G2/M cells. The level of this interaction between SUMOylated HSF2 and CAP-G was higher in G2/M cells than G0/G1 or S cells [63]. These results suggested that HSF2 binds to the HSP70 promoter in a mitosis-dependent manner and prevents the compaction of this promoter; they hypothesized that HSF2 has an important role in HSP70 bookmarking
We briefly described the early essential findings in cell cycle studies and the discovery of the heat shock response and essential functions of Heat shock transcription factors (HSFs) and referred to the important discoveries to date
Summary
The mitosis phenomenon was discovered over one hundred years ago, and many scientists have performed experiments to make novel discoveries. Paul Nurse and his colleagues made valuable discoveries They used temperaturesensitive mutants of the fission yeast Schizosaccharomyces pombe, different from the budding yeast Saccharomyces cerevisiae that Hartwell used, and found that their mutants have genetic mutations involved in cell size control over DNA synthesis and a second control acting on nuclear division [30]. They discovered that cdc-2 gene product activity is important for determining when mitosis takes place and is required for starting and controlling mitosis. - Mutant HSF1 affects cell cycle progression and arrest. - Higher expression of HSF1 is related to cancer and aneuploidy
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