Abstract
After mitosis, cells must physically separate from one another in a process known as cytokinesis. Failure of cytokinesis can promote tumorigenesis. Yoshida et al. examined how cell cycle signals are linked to the control of Rho-type GTPases and cytokinesis. Using budding yeast as a model, the authors identified a conserved signaling pathway whereby the mitotic polo kinase controls contractile ring assembly by directly regulating Rho1, the small guanosine triphosphatase that is required for cytokinesis in all eukaryotes. S. Yoshida, K. Kono, D. M. Lowery, S. Bartolini, M. B. Yaffe, Y. Ohya, D. Pellman, Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science 313 , 108-111 (2006). [Abstract] [Full Text]
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