Cell Cycle Control in Fission Yeast and Mammals: Identification of New Regulatory Mechanisms

Abstract

Publisher Summary This chapter discusses the recent rapid progress in understanding of the molecular mechanisms controlling the G1 and G2 phases of the cell cycle in fission yeast and mammals, focusing on the newly identified control genes and highly conserved control mechanisms between these two apparently remote organisms. The cells of the fission yeast, Schizosaccharomyces pombe, are rod shaped, grow in the longitudinal direction, and divide by septation and medial fission. The chapter describes the cell cycle starts control of fission yeast and mammals. The mitotic start control of fission yeast and mammals have also been described in the chapter. Cell cycle control is one of the most complex and fundamental cellular regulatory processes that eukaryotes possess. Cell cycle control is one of the most complex and fundamental cellular regulatory processes that eukaryotes possess. Once cells have committed to start the cell cycle, they are unable to differentiate until they return to G1. The next few years will be the period during which rapid progress continues to be made and will witness the discovery of new factors and new mechanisms and the resolution of some of these questions.