Abstract
I was greatly impressed by an article recently published in Nature Methods (1), in which intracellular autofluorescence was characterized as a biomarker for epithelial cancer stem cells (CSCs). Interestingly, this epithelial CSC-specific autofluorescence was also associated with a highly invasive and chemoresistant phenotype. Riboflavin (vitamin B2) – an ABCG2-selectively transported substrate – was identified, after autophagy had been ruled out, as the source of cell autofluorescence (1).
Highlights
A commentary on Intracellular autofluorescence: a biomarker for epithelial cancer stem cells by Miranda-Lorenzo I, Dorado J, Lonardo E, Alcala S, Serrano AG, Clausell-Tormos J, et al Nat Methods (2014) 11:1161–69. doi:10.1038/ nmeth
I was greatly impressed by an article recently published in Nature Methods (1), in which intracellular autofluorescence was characterized as a biomarker for epithelial cancer stem cells (CSCs)
I have concerns about the fact lipofuscin was not included by the aforementioned authors among the putative causes of epithelial CSC autofluorescence
Summary
A commentary on Intracellular autofluorescence: a biomarker for epithelial cancer stem cells by Miranda-Lorenzo I, Dorado J, Lonardo E, Alcala S, Serrano AG, Clausell-Tormos J, et al Nat Methods (2014) 11:1161–69. doi:10.1038/ nmeth.3112. A commentary on Intracellular autofluorescence: a biomarker for epithelial cancer stem cells by Miranda-Lorenzo I, Dorado J, Lonardo E, Alcala S, Serrano AG, Clausell-Tormos J, et al Nat Methods (2014) 11:1161–69. I was greatly impressed by an article recently published in Nature Methods (1), in which intracellular autofluorescence was characterized as a biomarker for epithelial cancer stem cells (CSCs).
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