Abstract
Hematopoietic stem and progenitor cells (HSPC) express at their surface an array of cell adhesion receptors that enables them to interact with extracellular matrix components and transmembrane cell adhesion molecules expressed within stem cell niches in the bone marrow. Herein, we review the different cell adhesive interactions taking place within the bone marrow between HSPC and their niches (via integrins, CD44, selectin ligands, and Eph receptors) and how they support HSPC anchoring in the bone marrow and regulate HSPC fate during hematopoiesis. We review how malignant hematopoietic cells utilize adhesive interactions to resist chemotherapy treatments. Finally, we review how these adhesive interactions can be therapeutically targeted to increase HSPC mobilization for transplantation and to chemosensitize malignant hematopoietic cells to chemotherapy.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
