Cell Adhesion Molecules in Neural Stem Cell and Stem Cell- Based Therapy for Neural Disorders

Abstract

Neural stem/progenitor cells (NS/PCs), found in both the developing and the adult mamma‐ lian central nervous system (CNS), are a heterogeneous population of multipotent cells with the potential to self-renew by symmetric cell division or to differentiate into neurons, astrocytes and oligodendrocytes through asymmetric cell division (Gage, 2000; Alvarez-Buylla et al., 2001; Temple, 2001; Gotz and Huttner, 2005). NS/PCs have been found in almost all regions of the developing mammalian CNS, including the basal forebrain, cerebral cortex, ganglionic eminence, hippocampus, cerebellum, neural crest and spinal cord (Temple, 2001). Throughout development, NS/PCs give rise to neurons and glial cell populations of the CNS. In the adult CNS, NS/PCs are mainly found in the subventricular zone (SVZ) and subgranular layer (SGL) of hippocampal dentate gyrus (DG) (Goritz and Frisen, 2012). The ependymal cells lining the central canal of spinal cord of the adult mouse could be another potential source of adult NS/ PCs (Meletis et al., 2008). Because neurogenesis and gliogenesis occur during different stages of mammalian brain development, it was long assumed that neurons and glial cells in the CNS were generated from distinct precursor populations, known as early-embryonic, late-embry‐ onic, and adult NS/PCs. However, abundant evidence has since now demonstrated that embryonic and adult NS/PCs are likely lineage-related. Neuroepithelial cells behaving as NS/ PCs during very early developmental stages of the mammalian CNS give rise to radial glial cells around embryonic day 12 (E12). As the progeny of neuroepithelial cells, radial glial cells act as NS/PCs in the fetal and perinatal brain, and develop into astrocyte-like stem cells in the adult brains. Astrocyte-like adult stem cells function as stem cells to generate new nerve cells in the adult mammalian CNS. (Doetsch et al., 1999; Alvarez-Buylla et al., 2001; Merkle et al., 2004; Merkle and Alvarez-Buylla, 2006).