Abstract
IntroductionCeliac disease can be severe and associated with progressive malabsorption and death. A subset of patients may develop subepithelial collagen deposition, a condition referred to as collagenous sprue.Case presentationWe report a case of a 46-year-old female who was previously diagnosed as having seronegative arthritis and inflammatory bowel disease, and three years later after the initial diagnosis she was histologically confirmed to have celiac disease in association with collagenous sprue, another underlying malabsorptive disorder.ConclusionAlthough the precise relationship between celiac disease and collagenous sprue has been debated and remains controversial, it should be considered among the differential diagnoses of chronic diarrhea with progressive malabsorption.
Highlights
Celiac disease can be severe and associated with progressive malabsorption and death
Celiac disease (CD) is a disorder characterized by mucosal inflammation and villous atrophy of small bowel, leading to symptoms of malabsorption such as steatorrhea, weight loss or other signs of nutrient or vitamin deficiency
The patient was diagnosed with CD based upon serological and histological findings with compatible clinical and laboratory manifestations and noticeable clinical improvement was observed on a gluten-free diet within several days
Summary
Celiac disease (CD) is a disorder characterized by mucosal inflammation and villous atrophy of small bowel, leading to symptoms of malabsorption such as steatorrhea, weight loss or other signs of nutrient or vitamin deficiency. The diagnosis is presumptively established when there is concordance between the serologic results and the biopsy findings. It is confirmed when symptoms resolve subsequently on a gluten-free diet. Collagenous sprue (CS) is a rare disease of the small bowel, which is characterized by complete atrophy of mucosal villi and excessive collagen deposition in the lamina propria. It may cause a life threatening clinical picture. CD was histologically confirmed by duodenal biopsies, which revealed total villous atrophy of duodenal mucosa and regenerative hyperplasia. She was asked to avoid taking gluten and her complaints abated and did not persist
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