Celiac Disease and Type 1 Diabetes Mellitus Association: A Retrospective Analysis of Pediatric Cases in ROME

Abstract

sumption (>4 cups per day) and current illicit drug use. RESULTS: Of 656 responses, 202 patients with biopsy proven CD (79% female, avg age 45.6), 83 IBD (53% female, avg age 38.6), 198 C (63% female, avg age 49.5) were analyzed. The 3 groups differed significantly in age and sex (p<0.0001). 47 (23%) Chronic headaches were reported by 64 (32%) of CD, 14 (17%) of IBD and 59 (30%) of C. The CD group had significantly higher prevalence of migraine (22%) compared to controls (11%), p= 0.0040, while the prevalence of migraine in IBD patients (14%) was comparable to that of controls (p=0.1574). On multivariate logistic regression, female sex was an independent predictor of migraine (OR 3.69 95%CI 1.66-8.17). Daily opioid, NSAID or Trazodone use showed a trend towards an independent predictor ( OR 4.26 95% CI 0.98-8.57), as did OCP or HRT use (OR 2.16 95%CI 0.974.82). Age and depression were not independent predictors of migraine. After correcting for age, sex, HRT/OCP use, Opioids/NSAIDs/Trazodone use and depression/anxiety the CD group still had significantly higher prevalence of migraine headaches compared to C (OR 1.83, 95% CI 1.02-3.28), whereas the IBD group had similar incidence of migraine to C (OR 1.42, 95% CI 0.61-3.28). There was no correlation between years on gluten-free diet and severity of migraine as assessed by the HIT-6. CONCLUSIONS: Our finding of significantly higher rates of migraine in patients with CD suggests that migraine is a common neurologic manifestation of CD. Screening with CD serologies among migraine patients and studying the effect of gluten-free diet in migraine patients with CD is needed.