Abstract
Celastrol is a pentacyclic triterpene extracted from the roots of the traditional Chinese medicine Tripterygium Wilfordi (thunder god vine) plant. Recent studies demonstrated that celastrol could suppress food intake and increase energy expenditure thus playing a powerful role in losing weight. The detailed mechanisms included activating the leptin receptor-signal transducer and activator of transcription 3 signal pathway and reducing hypothalamic endoplasmic reticulum stress to potentiate leptin′s effect, activating heat shock factor 1-peroxisome proliferator-activated receptor γ coactivator-1α axis to promote energy metabolism and inhibiting nuclear factor κB signal pathway to improve insulin resistance. All of these findings make celastrol as a potential novel drug to treat obesity in the future. Key words: Celastrol; Leptin; HSF1-PGC1α axis; Nuclear factor-κB; Obesity
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