Abstract
DRESS (Drug reaction with eosinophilia and systemic symptoms) syndrome is a rare, potentially life-threatening, drug induced hypersensitivity reaction manifested by fever, rash, eosinophilia, lymphadenopathy, and organ involvement especially liver and kidney. The disease is characterized by a long latency period (at least two weeks) between the drug exposure and disease onset. The most commonly reported drugs associated with DRESS syndrome in the literature are allopurinol, and anticonvulsants. We describe a patient presented with eosinophilia, fever, diffuse maculopapular rash, hepatomegaly, and multiple intra-abdominal lymphadenopathies just ten days after initiation of cefuroxime axetil. In our case, we aim to announce the first case report of cefuroxime axetil related DRESS syndrome, and also speculate on the possible association between cephalosporin and DRESS syndrome.
Highlights
Dress syndrome is an idiosyncratic drug reaction often occurring after drug use and characterized by multiple internal organ involvement
Patient was admitted to the emergency service with the complaints of high fever, morbiliform skin rashes and
Dress syndrome was considered with the available data
Summary
Dress syndrome is an idiosyncratic drug reaction often occurring after drug use and characterized by multiple internal organ involvement. Dress syndrome has been described firstly after the use of anti-epileptic drugs. It has been named as hypersensitivity syndrome associated with anticonvulsant drug or drug associated pseudolymphoma [3,4]. Anti-epileptics and sulfonamides are the most common drugs that cause DRESS syndrome many drugs can cause it. Cefuroxime axetil is a semisynthetic antibiotic in the cephalosporin group. It has a bactericidal effect by disrupting cell wall synthesis. It is a good choice for the treatment of infections of respiratory and urogenital sys-. Correspondence: Yaşar Yıldırım Dicle Üniversitesi İç Hastalıkları ABD, Nefroloji BD
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