Abstract
Monotherapy with pencillin G or a first-generation cephalosporin or vancomycin hydrochloride administered for 4 weeks or 2-week therapy with penicillin together with an aminoglycoside are considered to be standard therapy for patients with penicillin-susceptible streptococcal infective endocarditis.<sup>1</sup>While these regimens are safe and effective therapy, experience with their use has been confined largely to the treatment of hospitalized patients. Prior to the report by Francioli et al<sup>2</sup>in this issue of<i>JAMA</i>, most authorities have been reluctant to use outpatient therapy in patients with See also p 264. infective endocarditis because of concern about the development of complications during therapy. The study by Francioli and colleagues is important for several reasons. First, this report confirms and extends a previous study by Stamboulian et al<sup>3</sup>demonstrating that 4 weeks of ceftriaxone sodium administered in a single daily dose is effective therapy for patients with penicillin-susceptible streptococcal infective endocarditis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
