Abstract
Abstract The increasing number of infections caused by multidrug-resistant gram-negative bacteria in children is a serious problem all over the world. Ceftazidim-avibactam is a promising antimicrobial drug recently approved in Russia for use in pediatric practice. This review provides information on the possible use of ceftazidime-avibactam in children with complicated intraabdominal infections (in combination with metronidazole); complicated urinary tract infections, including pyelonephritis; hospital-acquired pneumonia, including ventilator-associated pneumonia; infections caused by aerobic gram-negative microorganisms in patients with limited choice of antibacterial therapy. Based on the data on the in vitro activity of the drug, the results of clinical studies of pharmacokinetics, safety and efficacy of ceftazidimeavibactam for the treatment of infections in children the main clinical cases in which the use of ceftazidimeavibactam in pediatric practice is most justified and appropriate are identified.
Highlights
Межрегиональная ассоци ация по клинической микро биологии и антимикробной химиотерапии Научно-исследовательский ин ститут антимикробной химио терапии ФГБОУ ВО СГМУ Минздрава России
This review provides information on the possible use of ceftazidime-avibactam in children with complicated intraabdominal infections; complicated urinary tract infections, including pyelonephritis; hospital-acquired pneumonia, including ventilator-associated pneumonia; infections caused by aerobic gram-negative microorganisms in patients with limited choice of antibacterial therapy
Shek E.A., Sukhorukova M.V., Eidelstein M.V., Skleenova E.Yu., Ivanchik N.V., Shaydullina E.R., et al Antibiotic resistance, carbapenemase production and genotypes of nosocomial strains of Acinetobacter spp. in hospitals in Russia: results of the multicenter epidemiological study "MARATHON 2015-2016"
Summary
Баранцевич Н.Е., Леванова В.В., Баранцевич Е.П. 117 Региональные особенности распространения Candida auris. 161 Резолюция по итогам совещания экспертов Российской Федерации по вопросам вакцинопрофилактики пневмококковых инфекций у взрослых
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