Abstract
Ceftazidime pentahydrate/avibactam sodium (Avycaz–Actavis) is the second combination of a cephalosporin and beta-lactamase inhibitor to be marketed, joining ceftolozane/tazobactam (Zerbaxa). Ceftazidime is a cephalosporin antibacterial agent that has been available as a single agent for many years. Avibactam is the new beta-lactamase inhibitor that protects ceftazidime against inactivation by beta-lactamase enzymes, thereby increasing the activity of the antibacterial agent against gram-negative bacteria. Avibactam is a nonbeta-lactam and may inhibit certain bacteria-produced beta-lactamases that are not inhibited by other beta-lactamase inhibitors (e.g., tazobactam, sulbactam). Of particular importance is the activity of the new combination against gram-negative bacteria that produce Klebsiella pneumoniae carbapenemase. Daniel A. Hussar, PhD, Remington Professor of Pharmacy, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA Joellen Friedman, Student Pharmacist, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA
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