Ceftazidime and Vancomycin Deposits after Intravitreal Injection in a Vitrectomized Eye

Abstract

A 62-year-old man was referred on suspicion of exogenous endophthalmitis 3 weeks after pars plana vitrectomy to remove retained lens fragments, following a complicated phacoemulsification 2 months before presentation. Five days prior to his referral, endophthalmitis was suspected, and he underwent a vitreous tap and received intravitreal injections of ceftazidime and vancomycin. Left posterior segment examination showed multiple, diffuse, whitish, preretinal deposits, without chorioretinal lesions or vascular involvement (Fig A). OCT conducted through the lesions confirmed the preretinal location (Fig B). After 1 week, the deposits had reduced in size and number, and migrated inferiorly (Fig C). After 4 weeks, the deposits had resolved completely (Fig D). (Magnified version of Fig A-D is available online at www.aaojournal.org). Supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health.