Abstract
Objective: In the present investigation, fast dissolving tablets of cefpodoxime proxetil were formulated using superdisintegrants to impart fast disintegration.
 Methods: In the current study, 12 formulations of fast dissolving tablets of cefpodoxime proxetil were formulated using two different approaches viz., direct compression and sublimation. Three different superdisintegrants viz., croscarmellose sodium, sodium starch glycolate, and crospovidone were used in a different concentration in all the respective formulations. The final powder blend was subjected for the pre-compression evaluation and all the formulations were evaluated for post-compression parameters. Stability studies were also evaluated for the best formulations as per ICH guidelines. Finally, results were statistically analyzed by the application of one way ANOVA test and t-test.
 Results: Among all the formulations of different approaches, formulation cefpodoxime proxetil 4 (CP4) containing 6% crospovidone as a super disintegrant was showed the best results. In vitro dissolution data revealed that formulation CP4 prepared by direct compression method showed 99.387±0.270% drug release within 15 min whereas the percentage release by formulation prepared by using sublimation showed 83.927±0.735% release. The optimized formulation was further subjected to comparative in vitro study with two marketed formulation of different brands.
 Conclusion: All the data of all formulations is shows that direct compression approach is the best approach for developing the fast dissolving tablets to enhance the onset of action and bioavailability.
Highlights
The most suitable and widely acceptable delivery system for drug administration is the oral drug delivery system because of its selfadministration; compactness and easy manufacturing [1]
Cefpodoxime proxetil was observed for organoleptic properties like physical appearance, odor, and melting point
Differential scanning calorimeter shows endothermic fusion peak at 110.45 C, which was corresponding to the melting point of cefpodoxime proxetil
Summary
The most suitable and widely acceptable delivery system for drug administration is the oral drug delivery system because of its selfadministration; compactness and easy manufacturing [1]. Oral drug delivery system is becoming important day by day due to its fine characteristics; no invasion, no pain, easy to handle and patient compliance [2]. Pediatrics and geriatrics patients suffer a lot from the dysphagia (difficulty in swallowing) which leads to poor patient compliance [4]. To improvise such issues novel drug delivery system is come in existence called fast dissolving tablets (FDTs)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pharmacy and Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
