Abstract
The review study work comprises of interaction studies of cefixime with different group of drugs and metals to know about the alteration in pharmacological activity of cefixime by other drugs or vice versa. Cefixime is included among the cephalosporin third generation drug class which is active against a wide range of Gram positive and Gram negative bacteria. Since the presence of different therapeutic class of drugs like cefixime may affect the bioavailability as well as pharmacokinetics of other drugs and metal in the blood or tissues, therefore in order to study the potential interaction of cefixime with different therapeutic class of drugs and metals which can show several type of toxicity or may develop drug resistance in the body is the main reason to perform this study. About 102 articles were screened from different databases related to Cefixime and its interaction for this review. This review study claims that there is a possible interaction between cefixime and other drugs& metals which are confirmed by different method like GLC, HPLC, and Disk Diffusion Method. Drug resistance and unwanted adverse drug reactions are a common thing for different underlying factors which becomes an alarming issue. That’s why this is significant.
Highlights
A drug interaction is a situation in which a substance affects the activity of a drug when both are administered together
Cefixime is included among the cephalosporin third generation drug class which is active against a wide range of Gram positive and Gram negative bacteria
This review study claims that there is a possible interaction between cefixime and other drugs& metals which are confirmed by different method like GLC, HPLC, and Disk Diffusion Method
Summary
A drug interaction is a situation in which a substance affects the activity of a drug when both are administered together This action can be synergistic or antagonistic or a new effect can be produced that neither produces on its own. People taking anti depressant drugs such as monoamine oxidize inhibitors should not take food containing tyramine as hypertensive crisis may occur These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances [2]. Some classic examples of this type of interaction include that thiopentone and suxamethonium should not be placed in the same syringe and same is true for benzylpenicillin and heparin These situations will all be discussed under the same heading due to their conceptual similarity [8]. For this mechanism or activity, it gives some unwanted activity of its own or towards other drugs which can form a resistance of its own which is not desirable
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
