Cefepime‐induced delirium

Abstract

Cefepime is a fourth‐generation cephalosporin widely used to treat severe infections. However, some patients are at a disproportionately higher risk of developing cefepime‐induced encephalopathy (CIE). While CIE presenting as delirium is not uncommon, it is often missed in clinical practice. Current guidelines recommend prescribing cefepime adjusted for renal clearance to reduce the risk of toxicity. However, this rare case suggests adjusting cefepime for renal dysfunction may be insufficient to prevent CIE. Thus, clinicians must continuously evaluate patients on cefepime therapy to promptly diagnose CIE.