Abstract
Conventional chemotherapy against hepatocellular carcinoma typically causes various side effects. Our previous study showed that cecropin of Musca domestica can induce apoptosis in human hepatocellular carcinoma BEL-7402 cells in vitro. However, whether cecropin inhibits BEL-7402 cell in vivo and the question of possible side effects remained undentified. The present study confirmed tumor-inhibitory effects of cecropin in vivo, and furthermore strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action. Specifically, we found that cecropin exerted no obvious side effects in tumor-bearing mice as it had no significant hematoxicity as well as visceral toxicity. Therefore, cecropin may be a potential candidate for further investigation as an antitumor agent against hepatocellular carcinoma.
Highlights
Hepatocellular carcinoma is one of the most deathleading visceral neoplasms worldwide (Sener et al, 2005; Somboon et al, 2014)
The present study confirmed tumor-inhibitory effects of cecropin in vivo, and strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action
Our previous study demonstrates that cecropin can efficiently inhibit human hepatocellular carcinoma cell (BEL-7402) growth in vitro
Summary
Hepatocellular carcinoma is one of the most deathleading visceral neoplasms worldwide (Sener et al, 2005; Somboon et al, 2014). The most widely used agent against hepatocellular carcinoma is doxorubicin, either as a single agent or in combination with other chemotherapeutics like cisplatin (Giglia et al, 2010). This conventional chemotherapy has shown various side effects, for example hepatotoxicity (Injac et al, 2008; Fatemeh et al, 2013) and hematotoxicity (Sostelly et al, 2013), which complicates safe administration of systemic therapy. Our previous study has shown that cecropin can inhibit the proliferation and promotes the apoptosis of human hepatocellular carcinoma BEL7402 cells (Jin XB et al, 2010). Whether cecropin inhibits human hepatocellular carcinoma cell in vivo and exerts no side effects remains unexplored
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