CE-03 Organ-specific systemic lupus erythematosus activity during pregnancy is associated with adverse pregnancy outcomes

Abstract

Background Previous studies have found a relationship between overall systemic lupus erythematosus (SLE) activity and adverse pregnancy outcomes. We sought to investigate whether 5 types of specific types of SLE activity either in the 6 months prior to conception or during pregnancy were related to adverse pregnancy outcome. Materials and methods 149 pregnancies occurred in 114 women with mean age 23.7 (SD 6.8) years at SLE diagnosis and 31.0 (SD 5.3) at conception. 68% were White, 15% Hispanic, 11% Black, 7% Asian. Seven women had a history of antiphospholipid syndrome and 23 had a prior adverse pregnancy outcome. During the study period, 40 (27%) pregnancies had an adverse outcome. Cytopenias (15%) and nephritis (11%) were the most common types of SLE activity during pregnancy. In univariable analyses, nephritis 6 months before conception (OR 7.3, 95% CI: [1.5, 35.2]) and during pregnancy OR 4.4 (1.3–14.9) and cytopenias during pregnancy (OR 4.8 [1.7, 14.0]) were significantly associated with adverse outcome. Hispanic ethnicity, prior adverse pregnancy outcome, and steroid and/or azathioprine use during pregnancy were also associated with adverse outcome. In multivariable analyses, nephritis (OR 3.5 [1.0–12.2]), cytopenias (OR 4.2 [1.4,12.2]) and serositis (OR 5.7 [1.1–30.3]) during pregnancy were associated with adverse outcome (Table 1) Results 149 pregnancies occurred in 114 women with mean age 23.7 (SD 6.8) years at SLE diagnosis and 31.0 (SD 5.3) at conception. 68% were White, 15% Hispanic, 11% Black, 7% Asian. Seven women had a history of antiphospholipid syndrome and 23 had a prior adverse pregnancy outcome. During the study period, 40 (27%) pregnancies had an adverse outcome. Cytopenias (15%) and nephritis (11%) were the most common types of SLE activity during pregnancy. In univariable analyses, nephritis 6 months before conception (OR 7.3, 95% CI: [1.5, 35.2]) and during pregnancy OR 4.4 (1.3–14.9) and cytopenias during pregnancy (OR 4.8 [1.7, 14.0]) were significantly associated with adverse outcome. Hispanic ethnicity, prior adverse pregnancy outcome, and steroid and/or azathioprine use during pregnancy were also associated with adverse outcome. In multivariable analyses, nephritis (OR 3.5 [1.0–12.2]), cytopenias (OR 4.2 [1.4,12.2]) and serositis (OR 5.7 [1.1–30.3]) during pregnancy were associated with adverse outcome (Table 1). Conclusions The majority of pregnancy outcomes were favourable in this SLE cohort. After adjusting for ethnicity, prior adverse pregnancy outcomes, and medications during pregnancy, nephritis, cytopenias and serositis disorders during pregnancy were associated with an elevated risk of adverse pregnancy outcome. Prior studies have suggested variable impact of lupus nephritis on pregnancy outcomes, but this study uniquely demonstrates an additional association between cytopenias and serositis during pregnancy and adverse pregnancy outcomes.