Cdx1 expression inhibits cyclin D1 and c-Myc expression and β-catenin/TCF transriptional activity in human colon cancer cells

Abstract

(the number of swallows and time to raise esophageal pH to 5 after a 15 ml 0.1 N HC1 bolus) were performed in othewise heafihy heartburn sufferers before and after 2 Turns EX (1500 mg CaCO3). Differences were determined by paired t-tests, P<O. 05. Results: LESP was significantly increased after Tums (17.8 vs 29.4 mmHg, P<0 001, N = 15). Depth of LES relaxation, medial and distal esophageal contractile amplitude, and duration of contractions were not significantly altered after Tums Proximal contractile amplitude was significantly increased after Turns (48.4 vs 544 mmHg, P<0.0I) and velocity was significantly decreased after Turns (4.08 vs 3.6 cm/sec, P<O.009). Acid clearance was significantly increased alter Tunas (21 vs 10 swallows, P<0.0002 and 1091 vs 4.91 rain, P<0.017, N = 1.0). Salivary secretion and pH were not significantly altered by rums in a sub-set of these subjects, nor did saliva preand post-Turns neutrahze the acid bolus. Summary: Luminal Ca in chewable CaCO3 significantly increases resting LESP, enhances esophageal acid clearance, and improves initiation of peristalsis. Conclusions: The Ca in chewable antacids intpmves 1) the tone of the reflux barrier, 2) initiation of peristalsis, and 3) acid clearance. The increased acid clearance cannot be explained by neutralization of the acid by the antacid, nor by a change in salivary secretion. Our data provide a scientific basis for the continued use of chewable Ca carbonate antacids for heartburn and reflux management.