Abstract
Abstract The influence of coating a CdTe quantum dots (QDs) layer on the 198Au nanoparticles (NPs) in biodistribution of 198Au nanoparticles was investigated. The 198Au nanoparticles were prepared by irradiating the highly pure metallic gold in Tehran research nuclear reactor and subsequently 198Au-NPs were synthesized and subjected to surface modification with cysteamine and CdTe QDs to form an adduct. The prepared nanomaterials were characterized with X-ray diffraction, radio thin layer chromatography, transmission electron microscopy, and scanning electron microscopy. In-vivo biodistribution and tumor avidity studies were performed by intravenously injecting of cysteamine@198AuNPs: CdTe QDs nanocomposite into rats. The %ID/g (percent of the initial dose per gram tissue weight) in dissected organs and Fibrosarcoma tumor specimens was then measured. The hydrophilicity of the cysteamine@198AuNPs was increased by surface modification with CdTe QDs. Rapid excretion from body and high tumor uptake for cysteamine@198AuNPs: CdTe QDs revealed that this radiotracer could potentially be used in nuclear medicine as a theranostic agent.
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