Abstract
Water soluble CdTe quantum dots have shown potential as a platform for development of live cell imaging, but their cytotoxicity limits their biological applications. To decrease their cytotoxicity, an approach to modify CdTe quantum dots (QDs) with polyamidoamine (PAMAM) was employed by forming covalent bonds between them. The resultant nanocomposites as a cell imaging bioprobe for live PK15 and their in vitro toxicity were also investigated. The results showed that the prepared nanocomposites were able to enter PK15 cells with good biocompatibility and low cellular toxicity.
Highlights
Rapid advances in nanotechnology and nanoscience have spurred interests in developing a variety of nanostructure materials
We successfully prepared fluorescent CdTe-PAMAM dendrimer nanocomposites through covalent bonds by crosslinking agent EDC (Figure 1), the nanocomposites was characterized by TEM images, photoluminescence (PL) spectra
CdTe-PAMAM dendrimer nanocomposites were dispersed in the cytoplasm
Summary
Rapid advances in nanotechnology and nanoscience have spurred interests in developing a variety of nanostructure materials. QDs have potential applications in optoelectronics, biosensing, biolabelling and cell imaging[2,3]. PAMAM dendrimers are small enough to pass into the cell membrane and can be used to deliver substances such as drugs, genetic materials or chemical markers and make them potentially useful for many biological applications[7,11].
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