Abstract
Evidence is presented for a new heat-stable cofactor that is required for carbon dioxide reduction to methane by extracts of Methanobacterium thermoautotrophicum . This carbon dioxide reduction factor (CDR factor) is present in certain fractions of cell extract eluted from a DEAE-cellulose ion exchange column. The factor is required for reactions that involve methanogenic C 1 intermediates more oxidized than formaldehyde.
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