Abstract
We have isolated a second goldfish estrogen receptor (ER) β-subtype (gfER-β2) cDNA which is distinct from the liver-derived ER-β (gfER-β1) cDNA reported previously. The 2650-bp cDNA, isolated from a goldfish pituitary and brain cDNA library, encodes a 610 amino acid (aa) protein which shows only a 53% aa sequence identity with gfER-β1 in overall structure. RT-PCR analysis showed that mRNA of gfER-β2, in contrast to that of gfER-β1, was predominantly expressed in pituitary, telencephalon and hypothalamus as well as in liver of female goldfish. The existence of a second distinct ER-β subtype opens new dimensions for studying tissue-specific regulation of gene expression by estrogen in the tetraploid goldfish.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
