CD-MOFs: From preparation to drug delivery and therapeutic application

Yanxue Si,Huize Luo,Pai Zhang,Chunliang Zhang,Juanjuan Li,Peng Jiang,Wenbing Yuan,Ruitao Cha

doi:10.1016/j.carbpol.2023.121424

CD-MOFs: From preparation to drug delivery and therapeutic application

Yanxue Si, Huize Luo + Show 6 more

https://doi.org/10.1016/j.carbpol.2023.121424

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Journal: Carbohydrate Polymers	Publication Date: Sep 20, 2023
Citations: 11

Affiliation: China University of Geosciences (Beijing), National Center for Nanoscience and Technology, Hainan University, University of Chinese Academy of Sciences, Foshan University, National Institutes for Food and Drug Control

#Cyclodextrin Metal-organic Frameworks #Drug Loading Methods + Show 8 more

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Abstract

Cyclodextrin metal-organic frameworks (CD-MOFs) show considerable advantages of edibility, degradability, low toxicity, and high drug loading, which have attracted enormous interest, especially in drug delivery. This review summarizes the typical synthesis approaches of CD-MOFs, the drug loading methods, and the mechanism of encapsulation and release. The influence of the structure of CD-MOFs on their drug encapsulation and release is highlighted. Finally, the challenges CD-MOFs face are discussed regarding biosafety assessment systems, stability in aqueous solution, and metal ion effect.

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