Abstract
Lysophosphatidic acid (LPA) has been shown to stimulate transcellular migration of MM1 rat ascites hepatoma cells through transient activation of the Rho/ROCK pathway. Here we report that LPA also induces transient inactivation of Cdc42 and Rac1, both of which are required for transmigration of MM1 cells. Cdc42-induced shape change is a required step for LPA-induced MM1 cell migration. We provide evidence that MM1 cells transmigrate the mesothelial cell monolayer through activation of not only previously reported Rho/ROCK pathway but also Rac/WAVE2 and Cdc42/N-WASP pathways.
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