Abstract
In the fission yeast S. pombe the cdc25 + gene function is required to initiate mitosis. We have cloned the cdc25 + gene and have found that increased cdc25 + expression causes mitosis to initiate at a reduced cell size. This shows that cdc25 + functions as a dosage-dependent inducer in mitotic control, the first such mitotic control element to be specifically identified. DNA sequencing of the cdc25 + gene has shown that it can encode a protein of MW 67,000. Evidence is described showing that cdc25 + functions to counteract the activity of the mitotic inhibitor wee1 +, and indicating that both mitotic control elements act independently to regulate the initiation of mitosis.
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