Abstract
Objective To demonstrate the relationship between Cdc20 mutation and the promotion of colon cancer via Cdc20loxp/+ APCmin/+ villin-cre+/- compound mutant mice. Methods Cdc20loxp/+ APCmin/+ villin-cre+/- compound mutant mice and APCmin/+ mutant mice were generated by mice mating strategy. The colon tumors of two group mice were compared by phenotypic analysis and histology analysis. Results Phenotypic analysis showed that the number of tumors in Cdc20loxp/+ APCmin/+ villin-cre+/- compound mutant mice group and APCmin/+ mutant mice group was 1.2±0.5 and 1.6±0.5, respectively (t=0.215, P=0.588), and the maximum diameter of tumors was (2.7±0.3) cm and (2.5±0.2) cm, respectively (t=0.568, P=0.575). Pathologic type of Cdc20loxp/+ APCmin/+ villin-cre+/- compound mutant mice was adenocarcinoma, while that of APCmin/+ mice was tubular adenoma. Conclusion Cdc20 carrying a null allele can accelerate the promotion of colon cancer in APCmin/+ mice without influence on the tumor number and size. Key words: Colon neoplasms; Mice, mutant strains; Gene, Cdc20; Gene, APC
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
