Abstract
Dendritic cells prime CD8 T cells to proliferate and acquire effector function. However, how CD8 T cells could modulate DC function during this priming is less understood. Here, we show that activated CD8 T cells can prime DCs for IL‐12p70 in the presence of LPS. This ability was not seen with freshly isolated CD8 T cells or when LPS was absent. Direct contact involving MHC class I peptide and CD40‐CD40L interactions was essential for IL‐12p70 production, whereas soluble factors, including IFN‐g, TNF‐a, IL‐4 and GM‐CSF was little or no role to play in this process. CD8 T cells primed the CD8a+ but not the CD8a− DC subset for IL‐12p70 production. Hence apart from their role as killer cells, activated CD8 T cells may provide help to DCs via CD40L to pathogenically challenged CD8a+ DCs for IL‐12p70 and Th1 induction.This work is funded by the Biomedical Research Council (Grant no. 04/1/21/19/373). Wong KL is supported by an A*STAR graduate scholarship.
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