Abstract
Tolerance of heart or lung allografts have been achieved for the first time in nonhuman primates (NHPs) using a mixed chimerism conditioning regimen. However, the mechanisms leading to this state of unresponsiveness remain unclear. Transitional B cells have been recently highlighted for their IL-10-dependent suppressive capabilities and their potential to assist in Treg development and sustainability. Here, we assessed the prevalence of transitional B cells during leukocyte reconstitution in conditioned NHP recipients of combined bone marrow and heart or lung allografts.
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