CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients.

Mingming Jin,Shuang Sha,Nannan Shi,Yun Lin,Meng Wang,Shengjie Lu,Gang Huang,Hui Zhou,Yingmin Chen,Xuyuan Huang,Chunzi Shi,Yuxin Shi,Qing Chang,Kaiyi Liang

doi:10.18632/aging.103941

Abstract

The ongoing outbreak of COVID-19 has been announced by the World Health Organization as a worldwide public health emergency. The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. The results showed that the mortality of COVID-19 patients increased accompanied by age. Host factors CRP, IL-1β, hs-CRP, IL-8, and IL-6 levels in severe pneumonia patients were higher than in non-severe patients. CD3, CD8, and CD45 counts were decreased in COVID-19 patients. The results of this study suggest that the K-values of CD45 might be useful in distinguishing between severe and non-severe cases. The cut-off value for CD45 was -94.33. The K-values for CD45 in non-severe case were above the cut-off values, indicating a 100% prediction success rate for severe and non-severe cases following SARS-CoV-2 infection. The results confirmed that immune system dysfunction is a potential cause of mortality following COVID-19 infection, particularly for the elderly. CD45 deficiency dysfunction the naïve and memory T lymphocytes which may affects the long-term effectiveness of COVID-19 vaccines. K-values of CD45 might be useful in distinguishing between severe and non-severe cases in the early infection. May be CD45 could increase the diagnostic sensitivity.

Highlights

The ongoing outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), commonly referred to as coronavirus disease 2019 (COVID-19), has been announced by the World Health Organization (WHO) as a worldwide public health emergency [1]
The results showed that there was no difference in the rate of SARS-CoV-2 infection between the sexes
Total protein, albumin, and sodium levels were significantly lower in severe COVID-19 patients compared with non-severe COVID-19 patients, suggesting an abnormal liver function index in severe COVID-19 patients compared with non-severe COVID-19 patients

Summary

Introduction

The ongoing outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), commonly referred to as coronavirus disease 2019 (COVID-19), has been announced by the World Health Organization (WHO) as a worldwide public health emergency [1]. More than 190 countries have reported COVID-19 infections and more than three million people are currently infected worldwide. There are currently more than a million people infected in the United States. COVID-19 pneumonia was first reported in Wuhan, Hubei Province, China, in December 2019, and was www.aging-us.com followed by an outbreak across Hubei Province and other areas in the country. In China, through the unremitting efforts of the entire population, COVID-19 infections were under control by early March 2020 [3]. Regardless of where it originated, COVID-19 is a global disaster. China's experience in treating COVID19 patients may inform how other countries manage this outbreak. If an infection is confirmed, the individual should enter the emergency ward for treatment [4]

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