Abstract
CD44v6 has recently been reported as a biomarker for colorectal cancer. However, the clinical and prognostic significance of CD44v6 in colorectal cancer remains controversial. Therefore, we performed a meta-analysis to clarify this issue. A comprehensive literature search was performed using Medline, Embase and Web of Science, and the statistical analysis was conducted using Stata software. A total of twenty-one studies including 3918 colorectal cancer cases were included. The pooled analysis showed that CD44v6 overexpression in colorectal cancer was an independent prognostic marker correlating with lower 5-year overall survival rate (OR=0.78, 95%CI =0.67-0.91, p=0.001). CD44v6 overexpression was also associated with more lymph node invasion (OR=1.48, 95%CI= 1.02-2.15, p=0.04), and advanced Dukes stage (OR=2.47, 95%CI= 1.29-4.73, p=0.01). In addition, while excluding Zolbec's study, CD44v6 overexpression was associated with distance metastasis (OR=1.65, 95%CI =1.13-2.40, p=0.01). Taken together, this meta-analysis suggested that CD44v6 is an efficient prognostic factor in colorectal cancer.
Highlights
The treatments for colorectal cancer (CRC) have developed rapidly in recent years, CRC still remains one of the most commonly diagnosed cancers and the second leading cause of cancer-related death worldwide [1, 2]
Regarding the biological properties of Cancer-stem cells (CSCs), many studies suggested that evaluation of CD44, specially its variant isoform CD44v6 expression in CRC tissues may be useful in the future as a novel prognostic factor
Based on the previous studies, we performed this meta-analysis to systematically review the correlation between overexpression and clinical significance of CD44v6 in CRC
Summary
The treatments for colorectal cancer (CRC) have developed rapidly in recent years, CRC still remains one of the most commonly diagnosed cancers and the second leading cause of cancer-related death worldwide [1, 2]. CD44 is a glycosylated cell surface molecule which belongs to a family of hyaluronan binding proteins It is encoded by a single gene containing 20 exons and is located on the short arm of chromosome 11 (11p13), and has many variant isoforms generated by alternative splicing of at least 10 variant exons. Many studies have been conducted to explore the relationship between CD44v6 and the prognosis of CRC [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32]. To further clarify these issues, we conduct this meta-analysis including all of the evidence to date
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