Abstract
BackgroundRecent studies have focused on the diagnostic and prognostic significance of CD24 and CD44 expression in human cancers. This study aimed to explore changes in CD44 and CD24 expression levels in patients with gastric cancer and to assess their prognostic values.MethodsCD44 and CD24 expression levels were investigated immunohistochemically in tumor samples from 290 patients with non-cardia gastric adenocarcinoma, of whom 77 had paired adjacent normal gastric mucosa. CD24 and CD44 mRNA levels were determined by quantitative polymerase chain reaction in 34 patients. Serum anti-Helicobacter pylori IgG was detected by enzyme-linked immunosorbent assay. Relationships between CD44 and CD24 protein expression levels and tumor parameters were analyzed and their prognostic values were evaluated by Cox proportional hazards models.ResultsCD24 and CD44 expression levels were significantly higher in patients with gastric cancer compared with those in paired controls (45.5% vs. 0.0%, and 61.0% vs. 0.0%, P < 0.001). Among 290 patients, the overall survival rate was significantly higher in CD44(−) compared with CD44(+) patients (log-rank test, P = 0.035). However, there was no significant correlation between CD24 expression and overall survival time (log-rank test, P = 0.115). Multivariate regression analysis indicated that positive CD44 expression (P = 0.029), TNM staging (P < 0.001), and lymphovascular invasion (P = 0.016), but not CD24 expression (P = 0.065), were independent prognostic factors in gastric cancer.ConclusionsIndividual expression of CD44 was associated with poor survival in patients with gastric carcinoma.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-230X-14-157) contains supplementary material, which is available to authorized users.
Highlights
Recent studies have focused on the diagnostic and prognostic significance of CD24 and CD44 expression in human cancers
Yong et al recently investigated CD44/ CD24 expression in a retrospective analysis of patients with recurrent gastric cancer, but found no associations between individual or combined expression of CD24 and CD44 and the recurrence of gastric cancer [11]. Based on these previous studies, we hypothesized that CD24 and CD44 expression might be correlated with gastric cancer prognosis
CD24 and CD44 expression levels in gastric cancer CD24 and CD44 expression were detected in the membrane of cancer cells in gastric cancer samples (Figure 1)
Summary
Recent studies have focused on the diagnostic and prognostic significance of CD24 and CD44 expression in human cancers. Despite improvements in surgical techniques and the development of new chemotherapeutic regimens, there were 989,600 new cases, and more than 738,000 deaths worldwide in 2008 Half of these cases and deaths were estimated to occur in China. Yong et al recently investigated CD44/ CD24 expression in a retrospective analysis of patients with recurrent gastric cancer, but found no associations between individual or combined expression of CD24 and CD44 and the recurrence of gastric cancer [11]. Based on these previous studies, we hypothesized that CD24 and CD44 expression might be correlated with gastric cancer prognosis. We investigated the correlation between H. pylori infection and CD24/CD44 expression
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