Abstract
CD40L is critical for interactions required for Td humoral responses and for germinal center formation. The lack of germinal center formation in response to Td immunization suggests that CD40L is required for the development of memory Bcell responses. CD40L is required for Ig isotype switching in vivo for Td antigens, but not for Ti antigens. CD40L–/– cells are able to carry out isotype switching in vitro, indicating that the defect in Ig production lies in the delivery of T-cell help provided during Bcell differentiation. CD40L may influence negative selection processes by regulating the expression of costimulatory molecules on thymic cells. CD40L is not required for the generation of virus-specific CD8+ cytotoxic Tcell responses.
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