Year-end Sale % OFF 
Abstract
CD4 T-cell Activation and Reduced Regulatory T-cell Populations are Associated with Early Development of Cataracts among HIV-infected Adults in Uganda
Highlights
Cataracts contribute 12% of visual loss among HIV-infected adults (HIV-positive) in Uganda
The HIV-1 virus has been attributed to nonspecific intraocular inflammation which could serve as a contributing factor in the pathogenesis of cataracts [8]
Rakai Health Sciences Program (RHSP) is a collaborative program between the Uganda Virus Research Institute (UVRI), scientists at Makerere and Johns Hopkins Universities (MU and JHU) and intramural National Institutes of Health (NIH) via an International Center of Excellence in Research (ICER) award
Summary
Cataracts contribute 12% of visual loss among HIV-infected adults (HIV-positive) in Uganda. Immuno-pathogenesis of cataracts may differ among HIV-negative and HIV-positive individuals; the need for innovative therapeutic interventions for cataracts among HIV-positive adults. Among HIV-infected individuals in Uganda, cataracts contributed to up to 12% of visual loss [4,5]. The HIV-1 virus has been attributed to nonspecific intraocular inflammation which could serve as a contributing factor in the pathogenesis of cataracts [8]. Most studies to understand cataract development among HIV-infected adults have described various aetiological pathogens including CMV retinitis, herpes simplex and toxoplasmosis among the immune suppressed individuals [4,5,9]. There is limited data on specific immunological pathways that increase risk of cataracts during HIV infection and subsequently little has been reported about immune modulation in the management of cataracts
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
