Abstract
Methods Longitudinal PBMC samples were obtained from subjects with various outcomes of HHV-8 infection over many years in the Multicenter AIDS Cohort Study. The PBMC were tested by HLA A*0201 multimer staining specific for memory CD8 T cell epitopes of viral lytic and latency proteins, and polyfunctional flow cytometry to detect HHV8-specific, polyfunctional CD8 T cell populations. The effect of Treg was examined by depleting CD4CD25 cells.
Highlights
CD8 T cells are considered to play an important role in controlling human herpesvirus 8 (HHV-8/KSHV) infection
These T cell responses are non-robust compared to other herpesviruses, suggesting that they are under tight regulatory control
Longitudinal PBMC samples were obtained from subjects with various outcomes of HHV-8 infection over many years in the Multicenter AIDS Cohort Study
Summary
CD4 regulatory T cells Control CD8 T cell responses to human Herpesvirus 8 lytic and latency proteins Lauren Lepone*, Giovanna Rappocciolo, Paolo Piazza, Mariel Jais, Frank J Jenkins, Charles R Rinaldo From 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. Objectives CD8 T cells are considered to play an important role in controlling human herpesvirus 8 (HHV-8/KSHV) infection.
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