CD4 LYMPHOCYTE IN HIV / AIDS BEFORE AND AFTER ANTIRETROVIRAL THERAPY

Rangsang Bagus Prabowo,Fx Hendriyono,Dewi Indah Noviana Pertiwi

doi:10.20527/jbk.v13i2.4074

Abstract

Abstract: Human Immunodefficiency Virus (HIV) is a virus that decreases the human immunity system, therefore the infected people become susceptible to any kind of infections. Examination of CD4 lymphocyte count periodically is one of the antiretroviral therapy success indicators. The purpose of this research was to determine the difference of CD4 lymphocyte count before and after antiretroviral therapy at Ulin General Hospital Banjarmasin on 2013-2015. The method of this research was observational analytic with cross-sectional approach. The study population was 55 patients which were selected by inclusion and exclusion criteria. Results portrayed an increase of the CD4 lymphocyte count in 51 patients after being given four kinds of antiretroviral for 6 months with the mean increase in CD4 lymphocyte count was 92,72 cell/µL. Data analysis result with Wilcoxon test portrayed a difference of the CD4 lymphocyte count before and after antiretroviral therapy with p value=0,000. In conclusion, there was a significant difference of the CD4 lymphocyte count before and after antiretroviral therapy. Keywords: Human Immunodeficiency Virus, CD4, lymphocyt, antiretroviral therapy

Highlights

Human Immunodeficiency Virus (HIV) is a major problem that threatens Indonesia and many countries around the world.[1]
The variables studied in this research were the CD4 lymphocytes count before and after ARV therapy expressed in units of cells / μL calculated by Alere Pima CD4 tool in Immunoserology Division of Clinical Pathology Laboratory of Ulin General Hospital Banjarmasin
From total of 55 patients, there was an increase of CD4 lymphocytes count in 51 HIV patients (92. 73%) who received ARV therapy at Ulin General Hospital Banjarmasin for at least six months

Summary

Introduction

Human Immunodeficiency Virus (HIV) is a major problem that threatens Indonesia and many countries around the world.[1] HIV is a type of virus that lowers the immune system, the people infected with this virus become susceptible to various infections.[2] Acquired Immunodeficiency Syndrome (AIDS) is a stage of infection that occurs when the immune system is damaged and a person becomes susceptible to infection. A person has been diagnosed with AIDS when CD4 lymphocytes count falls below 200 cells / μL. HIV is found primarily in blood, sperm fluid, vaginal fluid and breast milk.[2,3]. On 2013, there were 174 new HIV cases in South Kalimantan.[5]

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