Abstract
Background In Systemic Sclerosis (SSc) the detrimental role of the immune system is a topic of great interest. In recent genetic association studies most genes identified to date are immunity related genes. A contribution of T-cells as important cytokine producing cells is shown and the skewing of this population can be an important player in the maintenance and progression of inflammation and fibrosis.
Highlights
In Systemic Sclerosis (SSc) the detrimental role of the immune system is a topic of great interest
The decreased production of IL-10 and interferon-g in limited SSc patients shows a decrease of Th1 and Treg involvement in this disease subset
A prospective study must show if these findings could contribute to the assessing the prognosis and the treatment of SSc patients
Summary
In Systemic Sclerosis (SSc) the detrimental role of the immune system is a topic of great interest. In recent genetic association studies most genes identified to date are immunity related genes. A contribution of T-cells as important cytokine producing cells is shown and the skewing of this population can be an important player in the maintenance and progression of inflammation and fibrosis. Together with a normal production of IL-13 this could create a proinflmmatory and profibrotic condition in this subset of patients. The decreased production of IL-10 and interferon-g in limited SSc patients shows a decrease of Th1 and Treg involvement in this disease subset. A prospective study must show if these findings could contribute to the assessing the prognosis and the treatment of SSc patients
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