Abstract
Peripheral suppression of autoreactive T cells by specialized T-cell populations is one of several mechanisms ensuring self-tolerance within the adaptive immune system. Thymus-derived CD4+CD25+ T cells expressing the transcriptional repressor FOXP3 mediate such immunoregulatory functions and are pivotal for the prevention of autoimmunity. As peripheral tolerance induction is a prerequisite for successful treatment outcome after allogeneic hematopoietic stem cell transplantation (HSCT), the role of CD4+CD25+ T cells in transplantation models and clinical trials is now under investigation in many laboratories. Here we summarize recent results regarding protection from graft-versus-host disease (GVHD) by adoptively transferred CD4+CD25+ T cells in mice and discuss early findings from clinical studies in HSCT.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
