Abstract
Th17 cells and CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells are thought to promote and suppress inflammatory responses, respectively. Here we explore why under Th17 cell polarizing conditions, Treg cells did not suppress, but rather upregulated, the expression of interleukin-17A (IL-17A), IL-17F, and IL-22 from responding CD4(+) Tcells (Tresp cells). Upregulation of IL-17 cytokines in Tresp cells was dependent onconsumption of IL-2 by Treg cells, especially at early time points both invitro and invivo. During an oral Candida albicans infection in mice, Treg cells induced IL-17 cytokines in Tresp cells, which markedly enhanced fungal clearance and recovery from infection. These findings show how Treg cells can promote acute Th17 cell responses to suppress mucosal fungus infections and reveal that Treg cellshave a powerful capability to fight infections besides their role in maintaining tolerance or immune homeostasis.
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