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Abstract
Background Reports on the expression of CD38 in Sézary syndrome (SS), erythrodermic primary cutaneous T cell lymphoma with leukemic involvement, are limited. The aim of the present study is the analysis of the expression of CD38 by skin-infiltrating mononuclear cells and circulating T lymphocytes in a cohort of SS patients. Methods SS patients diagnosed since 1985 in our clinic were retrospectively analyzed for CD38 expression in biopsy and blood samples by immunohistochemistry and flow cytometry, respectively. Results SS patients show a predominant CD38-negative phenotype on both skin and blood. A subgroup of patients was found expressing CD38 (12 cases) in either the skin (>25% cell infiltrate) or blood (CD4+CD38+ >50%), among whom 4 in the blood, 7 in the skin, and 1 in both blood and skin. Conclusion The implications of these observations may be twofold: the relevance in basic science is related to a potential role in immune defense regulation, whilst in perspective CD38 may become a target for antibody therapy, considering the availability of different anti-CD38 monoclonal antibodies.
Highlights
Reports on the expression of CD38 in Sézary syndrome (SS), erythrodermic primary cutaneous T cell lymphoma with leukemic involvement, are limited
This paper reports the results of a retrospective analysis of CD38 expression in skin and blood samples from a series of 76 SS patients diagnosed, treated, and followed up at the Dermatologic Clinic of the University of Turin since 1985
Our results confirmed that CD38 is not generally expressed by lymphoid cells in this group of patients, as reported in our previous study [2]
Summary
Reports on the expression of CD38 in Sézary syndrome (SS), erythrodermic primary cutaneous T cell lymphoma with leukemic involvement, are limited. Sézary syndrome (SS), the erythrodermic and leukemic variant in the spectrum of cutaneous T cell lymphomas (CTCL), is characterized by a clinical triad including erythroderma, enlarged peripheral nodes, and atypical circulating T lymphocytes with “cerebriform” nuclei [1]. The function of the CD38 molecule is pleiotropic, initially defined as receptor able to transduce activation signals; it was considered as an adhesion molecule with CD31 (PECAM-1) as counterreceptor. Another function of CD38 is to act as an ectoenzyme, able to metabolize extracellular nicotinamide adenine dinucleotide (NAD+)
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