Abstract
Purpose: CD38 is recently shown to be the main NADase in mammalian tissue, which contributes substantially to degradation of cellular nicotinamide adenine dinucleotide (NAD+), a key metabolite involved in cellular energy metabolism and adaptive responses of cells to bioenergetics and oxidative stress. CD38 expression and activity are increased during aging, which contributes to age-related decline of NAD+. In our previous studies, we observed an age-related increase in expression of CD38 in human knee cartilage, and that increased CD38 expression in chondrocytes is associated with reduced NAD/NADH levels and increased catabolic responses to pro-inflammatory cytokine IL-1β.
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