Abstract
The tumor microenvironment is immunosuppressive. Here we preview two recent studies from Ma etal. (2021) in Cell Metabolism and Xu etal. (2021) in Immunity that describe a key role of Tcell-expressed CD36 in enhancing lipid uptake and mediating lipid peroxidation that ultimately leads to CD8+ Tcell dysfunction, ferroptosis, and reduced anti-tumor function.
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