CD36‐Myeloperoxidase Connection and the Activation of Intestinal Fibroblasts

Abstract

Intestinal fibroblasts are mesenchymal cells that express CD36, which is a scavenger and membrane‐bound receptor with several functions including an indicator of inflammation, interacts with TLR‐2, 4, 6 and is a receptor for collagen. Recent evidence emphasizes the important role of CD36 in intestinal detection of fatty acids under physiologic conditions. Myeloperoxidase (MPO) is a heme protease predominantly released by leukocytes and functions to destroy pathogens, marks tissue for removal, and can bind high density lipoprotein (HDL). Given that HDL removes very low density lipoprotein (VLDL‐ “bad” cholesterol), having high levels of HDL is beneficial. Thus, we investigate the role of MPO (expressed by fibroblasts) and CD36 in intestinal fibroblasts. Both CD36‐deficient fibroblasts and CD36‐deficient mice appear to display less inflammation. Using immunopurification, MPO and CD36 appear to be connected on the surface of fibroblasts. There is a hereditary MPO deficiency that results in an increased susceptibility to infections (candida albicans). Thus, MPO‐deficient fibroblasts were examined for differences in expression and function of CD36; activity of CD36 is also connected to the activity of MPO. These results highlight the importance and impact of the connection of nutrition and immune function.Support or Funding InformationNational Science Foundation RII